Professor Paul McKeigue
Since 2007 Paul McKeigue has been Professor of Genetic Epidemiology and Statistical Genetics at the University of Edinburgh. He previously held tenured professorial posts at the London School of Hygiene & Tropical Medicine and University College Dublin.
His research interests have spanned a wide range of fields, from the epidemiology of diabetes and cardiovascular disease in ethnic minorities to genetic epidemiology. More recently he has focused on the development of Bayesian statistical methods in genetic epidemiology and related fields, including methods that exploit genetic variation to infer causal relationships between phenotypic biomarkers and outcomes. His work in the SHIP consortium includes the development of Bayesian methods that exploit health-case databases to infer associations of drug exposure with health outcomes.
His other current research is supported by grants from the MRC, NIH, and the European Commission. He has been a member of review panels for NIH, ESRC and Wellcome Trust, and currently sits on the Population Research Committeee of Cancer Research UK.
Recent Publications
- Bock, C. H., Schwartz, A. G., Ruterbusch, J. J., Levin, A. M., Neslund-Dudas, C., Land, S. J., Wenzlaff, A. S., Reich, D., McKeigue, P., Chen, W., Heath, E. I., Powell, I. J., Kittles, R. A. and Rybicki, B. A. "Results from a prostate cancer admixture mapping study in African-American men.," Hum Genet (126:5), 2009, pp. 637--642.
- Cameron, E. A., Martinez-Marignac, V. L., Chan, A., Valladares, A., Simmonds, L. V., Wacher, N., Kumate, J., McKeigue, P., Shriver, M. D., Kittles, R., Cruz, M. and Parra, E. J. "MGEA5-14 polymorphism and type 2 diabetes in Mexico City.," Am J Hum Biol (19:4), 2007, pp. 593--596.
- Chioza, B. A., Aicardi, J., Aschauer, H., Brouwer, O., Callenbach, P., Covanis, A., Dooley, J. M., Dulac, O., Durner, M., Eeg-Olofsson, O., Feucht, M., Friis, M. L., Guerrini, R., Kjeldsen, M. J., Nabbout, R., Nashef, L., Sander, T., Sirén, A., Wirrell, E., McKeigue, P., Robinson, R., Gardiner, R. M. and Everett, K. V. "Genome wide high density SNP-based linkage analysis of childhood absence epilepsy identifies a susceptibility locus on chromosome 3p23-p14.," Epilepsy Res (87:2-3), 2009, pp. 247--255.
- Everett, K. V., Chioza, B. A., Georgoula, C., Reece, A., Capon, F., Parker, K. A., Cord-Udy, C., McKeigue, P., Mitton, S., Pierro, A., Puri, P., Mitchison, H. M., Chung, E. M. K. and Gardiner, R. M. "Genome-wide high-density SNP-based linkage analysis of infantile hypertrophic pyloric stenosis identifies loci on chromosomes 11q14-q22 and Xq23.," Am J Hum Genet (82:3), 2008, pp. 756--762.
- Everett, K. V., Chioza, B., Aicardi, J., Aschauer, H., Brouwer, O., Callenbach, P., Covanis, A., Dulac, O., Eeg-Olofsson, O., Feucht, M., Friis, M., Goutieres, F., Guerrini, R., Heils, A., Kjeldsen, M., Lehesjoki, A.-E., Makoff, A., Nabbout, R., Olsson, I., Sander, T., Sir�n, A., McKeigue, P., Robinson, R., Taske, N., Rees, M. and Gardiner, M. "Linkage and association analysis of CACNG3 in childhood absence epilepsy.," Eur J Hum Genet (15:4), 2007, pp. 463--472.
- Martinez-Marignac, V. L., Valladares, A., Cameron, E., Chan, A., Perera, A., Globus-Goldberg, R., Wacher, N., Kumate, J., McKeigue, P., O'Donnell, D., Shriver, M. D., Cruz, M. and Parra, E. J. "Admixture in Mexico City: implications for admixture mapping of type 2 diabetes genetic risk factors.," Hum Genet (120:6), 2007, pp. 807--819.
- McKeigue, P. M., Campbell, H., Wild, S., Vitart, V., Hayward, C., Rudan, I., Wright, A. F. and Wilson, J. F. "Bayesian methods for instrumental variable analysis with genetic instruments ('Mendelian randomization'): example with urate transporter SLC2A9 as an instrumental variable for effect of urate levels on metabolic syndrome.," Int J Epidemiol (), 2010.
- Molokhia, M., McKeigue, P., Curcin, V. and Majeed, A. "Statin induced myopathy and myalgia: time trend analysis and comparison of risk associated with statin class from 1991-2006.," PLoS One (3:6), 2008, pp. e2522.
- Molokhia, M., Pathak, A., Lapeyre-Mestre, M., Caturla, L., Montastruc, J. L., des Centres Régionaux de Pharmacovigilance (CRPV), L. F. and McKeigue, P. "Case ascertainment and estimated incidence of drug-induced long-QT syndrome: study in Southwest France.," Br J Clin Pharmacol (66:3), 2008, pp. 386--395.
- Prince, M. J., de Rodriguez, J. L., Noriega, L., Lopez, A., Acosta, D., Albanese, E., Arizaga, R., Copeland, J. R. M., Dewey, M., Ferri, C. P., Guerra, M., Huang, Y., Jacob, K. S., Krishnamoorthy, E. S., McKeigue, P., Sousa, R., Stewart, R. J., Salas, A., Sosa, A. L., Uwakwa, R. and research group, 10/66. D. "The 10/66 Dementia Research Group's fully operationalised DSM-IV dementia computerized diagnostic algorithm, compared with the 10/66 dementia algorithm and a clinician diagnosis: a population validation study.," BMC Public Health (8), 2008, pp. 219.
- Tillin, T., Chaturvedi, N., Forouhi, N. G., Smith, G. D. and McKeigue, P. M. "Cardiovascular disease mortality in relation to childhood and adulthood socioeconomic markers in British South Asian men.," Heart (94:4), 2008, pp. 476--481.
- Tillin, T., Evans, R. M., Witt, N. W., Sharp, P. S., McKeigue, P. M., Chaturvedi, N. and Hughes, A. D. "Ethnic differences in retinal microvascular structure.," Diabetologia (51:9), 2008, pp. 1719--1722.
- Vitart, V., Rudan, I., Hayward, C., Gray, N. K., Floyd, J., Palmer, C. N. A., Knott, S. A., Kolcic, I., Polasek, O., Graessler, J., Wilson, J. F., Marinaki, A., Riches, P. L., Shu, X., Janicijevic, B., Smolej-Narancic, N., Gorgoni, B., Morgan, J., Campbell, S., Biloglav, Z., Barac-Lauc, L., Pericic, M., Klaric, I. M., Zgaga, L., Skaric-Juric, T., Wild, S. H., Richardson, W. A., Hohenstein, P., Kimber, C. H., Tenesa, A., Donnelly, L. A., Fairbanks, L. D., Aringer, M., McKeigue, P. M., Ralston, S. H., Morris, A. D., Rudan, P., Hastie, N. D., Campbell, H. and Wright, A. F. "SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout.," Nat Genet (40:4), 2008, pp. 437--442.